| Tbio | High mobility group nucleosome-binding domain-containing protein 3 |
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]
Comments
Property Summary
| NCBI Gene PubMed Count | 14 |
| Grant Count | 12 |
| R01 Count | 2 |
| Funding | $974,980.77 |
| PubMed Score | 12.31 |
| PubTator Score | 8.61 |
| Disease | Z-score | Confidence |
|---|---|---|
| Multiple myeloma 1,327 | ||
| chronic rhinosinusitis 512 | ||
| ovarian cancer 8,484 |
| Disease | log2 FC | p |
|---|---|---|
| Multiple myeloma | 1.690 | 0.001 |
| ovarian cancer | -1.400 | 0.000 |
| chronic rhinosinusitis | -1.043 | 0.034 |
| PMID | Text |
|---|---|
| 21947420 | The SNPs in the region of HMGN3 gene formed a tightly combined haplotype block in both Chinese and Caucasians. The results suggest that the genomic region containing HMGN3 gene may be associated with spine BS in Chinese. |
| 19651901 | loss of HMGN3 impairs glucose-stimulated insulin secretion and leads to a diabetic phenotype. |
| PMID | Year | Title |
|---|---|---|
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 21947420 | 2012 | Genome-wide association study identifies HMGN3 locus for spine bone size variation in Chinese. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
| 19651901 | 2009 | The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| More... |
