Property Summary

NCBI Gene PubMed Count 41
PubMed Score 71.72
PubTator Score 204.51

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 5.27201400988009E-22
atypical teratoid / rhabdoid tumor 4369 5.68083812240875E-7
glioblastoma 5572 3.39402136660265E-6
malignant mesothelioma 3163 3.42277207781841E-6
pediatric high grade glioma 2712 3.21350973845048E-5
psoriasis 6685 3.00216563308519E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 9.38131289868257E-4
group 3 medulloblastoma 2254 9.52427139537555E-4
lung cancer 4473 0.00175939588835821
invasive ductal carcinoma 2950 0.00790822390620492
medulloblastoma, large-cell 6234 0.00996955637472377
gastric carcinoma 832 0.0301810027231384

Expression

  Differential Expression (12)

Disease log2 FC p
malignant mesothelioma 1.300 0.000
psoriasis -2.100 0.000
atypical teratoid / rhabdoid tumor 1.600 0.000
glioblastoma 1.700 0.000
medulloblastoma, large-cell 1.200 0.010
pancreatic ductal adenocarcinoma liver m... 1.609 0.001
lung cancer -1.300 0.002
pediatric high grade glioma 1.200 0.000
group 3 medulloblastoma 1.800 0.001
lung carcinoma -1.700 0.000
gastric carcinoma 1.200 0.030
invasive ductal carcinoma -1.100 0.008

Synonym

Accession Q15642 B2R8A6 B7WP22 D6W645 O15184 Q53G22 Q5TZN1 Q6FI24 Q8NFL1 Q8TCY1 Q8TDX3 Q96RJ1
Symbols STP
CIP4
HSTP
STOT
TRIP-10

Gene

PDB

2CT4   2EFK   2KE4  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Opossum OMA Inparanoid
C. elegans OMA EggNOG
C. elegans OMA Inparanoid

Gene RIF (16)

PMID Text
26208639 results support a model in which AKAP350 recruits CIP4 to the centrosome, providing a centrosomal scaffold to integrate microtubule and actin dynamics, thus enabling centrosome polarization and ensuring cell migration directionality.
25823823 CIP4 promotes metastasis in Triple negative breast cancer and is associated with poor prognosis.
25203208 CIP4 controls cell-cell cohesion and is required for the acquisition of an invasive phenotype in breast tumors
25174397 CIP4 is a positive regulator of non small lung carcinoma metastasis and a potential poor prognostic biomarker in lung adenocarcinoma.
23915320 CIP4 plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease.
23644527 Study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering.
21299869 Trip10 regulates cancer cell growth and death in a cancer type-specific manner. Differential DNA methylation of Trip10 can either promote cell survival or cell death in a cell type-dependent manner.
20940394 CIP4 overexpression is associated with breast cancer.
19632321 Cdc42-Interacting Protein-4 and FNBP1L protein potentially regulate later events in Epidermal Growth Factor Receptor endocytic trafficking that limits compartmentalized EGFR signaling.
19631450 CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.
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AA Sequence

MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQ      1 - 70
QSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRK     71 - 140
FERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMP    141 - 210
QIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPG    211 - 280
DVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPP    281 - 350
SPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQ    351 - 420
REALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPP    421 - 490
DPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTIS    491 - 560
MAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN                                 561 - 601
//

Text Mined References (51)

PMID Year Title
26208639 2015 Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells.
25823823 2015 CIP4 promotes metastasis in triple-negative breast cancer and is associated with poor patient prognosis.
25416956 2014 A proteome-scale map of the human interactome network.
25203208 2014 The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.
25174397 2015 CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23915320 2013 CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes.
23644527 2013 CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
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