Tbio TEAD2 Transcriptional enhancer factor TEF-4

Protein Summary

Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Uniprot Accession IDs

• Q15562
• B4DTJ6
• M0R1T9
• Q8NA25
• Q96IG3

Gene Name

• TEAD2

Ensembl ID

• ENST00000311227
• ENSP00000310701
• ENSG00000074219
• ENST00000377214
• ENSP00000366419
• ENST00000539846
• ENSP00000437928
• ENST00000593945
• ENSP00000469640
• ENST00000598810
• ENSP00000472109
• ENST00000601519
• ENSP00000469672

Symbol

• TEF4
• ETF
• TEF4
• TEF-4
• TEAD-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
histone modification site profile	0.84
hub protein	0.75
biological process	0.71
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-4

DTO Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.89   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.89   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0