Tchem TEAD4 Transcriptional enhancer factor TEF-3

Protein Summary

Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15561
• H0Y308
• Q6MZR9
• Q8NEV5
• Q92883
• Q96BK2

Gene Name

• TEAD4

Ensembl ID

• ENST00000397122
• ENSP00000380311
• ENSG00000197905

Symbol

• RTEF1
• TCF13L1
• TEF3
• TEF3
• RTEF1
• TEF-3
• EFTR-2
• TEFR-1
• TCF13L1
• hRTEF-1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
transcription factor perturbation	0.84
disease perturbation	0.83
transcription factor binding site profile	0.73
cell type or tissue	0.72

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-3

DTO Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.16   (req: < 5)

Gene RIFs: 74   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.16   (req: >= 5)

Gene RIFs: 74   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0