Property Summary

NCBI Gene PubMed Count 162
Grant Count 27
R01 Count 17
Funding $1,541,979.83
PubMed Score 167.72
PubTator Score 277.41

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (4)

Disease log2 FC p
psoriasis -2.400 0.000
osteosarcoma -1.136 0.000
tuberculosis and treatment for 6 months -1.100 0.000
subependymal giant cell astrocytoma -1.970 0.016

Gene RIF (113)

PMID Text
26774283 that a dimer of the shelterin subunit TRF2 wraps approximately 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.
26748096 Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 and TRF2
26640040 TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and formation of telomeric ultrafine anaphase bridges, ultimately leading to stochastic loss of telomeric sequences.
26572976 These observations suggest that TRF2 is a good candidate for the attachment of telomeres to the nuclear envelope in somatic cells
26450775 Study demonstrates that TRF2 interacts with and is sumoylated by PIAS1 and RNF4 targets SUMO-conjugated TRF2 for ubiquitination, thereby decreasing its stability suggesting that TRF2 status provides a molecular switch that controls its level at telomeres.
26318724 Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
25908860 APB formation induced clustering of telomere repeats, telomere compaction and concomitant depletion of the shelterin protein TRF2 (also known as TERF2).
25753893 TRF2 is a specific target of miR-23a, and uncover a previously unknown role for miR-23a in telomere regulation and cellular senescence
25675958 Data show that full-length repressor activator protein 1 (Rap1) binds to full-length telomeric repeat binding factor 2 (TRF2) with high affinity and equimolar ratio.
25631672 The variability of genes encoding for TERF1 and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.
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AA Sequence

MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARR      1 - 70
GRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVS     71 - 140
RLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKN    141 - 210
KEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLT    211 - 280
MAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKL    281 - 350
DQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLN    351 - 420
SSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQ    421 - 490
KWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN                      491 - 542
//

Text Mined References (174)

PMID Year Title
26774283 2016 TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
26748096 2016 A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
26640040 2015 Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.
26572976 2015 Telomere Repeat-Binding Factor 2 Is Responsible for the Telomere Attachment to the Nuclear Membrane.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26450775 2015 PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2.
26318724 2015 Heregulin, a new regulator of telomere length in human cells.
25908860 2015 PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.
25753893 2015 Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.
25675958 2015 Human Rap1 modulates TRF2 attraction to telomeric DNA.
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