Property Summary

NCBI Gene PubMed Count 46
PubMed Score 452.61
PubTator Score 90.15

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 5.35981493802583E-19
atypical teratoid / rhabdoid tumor 4369 2.75996790531223E-7
lung cancer 4473 4.52567921399647E-7
colon cancer 1475 2.44551423905871E-6
non-inflammatory breast cancer 208 2.9645328675618E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 1.94766728333036E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.18481564448859E-5
ovarian cancer 8492 7.78288385426623E-5
sonic hedgehog group medulloblastoma 1482 1.06071500714639E-4
lung adenocarcinoma 2714 1.16690574582897E-4
primitive neuroectodermal tumor 3031 1.37157446901691E-4
invasive ductal carcinoma 2950 1.57672312737096E-4
pancreatic cancer 2300 2.99372281318014E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.2196407698543E-4
adrenocortical carcinoma 1427 4.55038446832548E-4
breast carcinoma 1614 5.66228934564209E-4
ductal carcinoma in situ 1745 0.00141597918226584
astrocytic glioma 2241 0.00684877985938751
oligodendroglioma 2849 0.0125226769125654
medulloblastoma, large-cell 6234 0.0177394047186548
pancreatic ductal adenocarcinoma liver metastasis 1795 0.02192786041679
Disease Target Count Z-score Confidence
Scurvy 10 4.228 2.1
hepatocellular carcinoma 550 3.549 1.8

Expression

Synonym

Accession Q15493 A4FTW1 A8K271 Q53FC9 Q5JRR5 RC
Symbols RC
GNL
SMP30
HEL-S-41

Gene

RGN

PANTHER Protein Class (2)

PDB

3G4E   3G4H   4GNB   4GNC  

  Ortholog (13)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid
S.cerevisiae EggNOG Inparanoid

Gene RIF (28)

PMID Text
26619319 Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis.
26171977 results highlighted the importance of RGN as a regulatory protein in Ca2+-dependent signaling pathways and its deregulation of RGN expression by Ca2+o may contribute for onset and progression of PCa.
26072307 immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients
25847529 data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells.
25230901 This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review]
25128811 RGN overexpression protected from carcinogen-induced mammary gland tumor development and was linked with reduced proliferation and increased apoptosis. These findings indicated the protective role of RGN in the carcinogenesis of mammary gland.
25050833 The alternatively spliced variants of the regucalcin gene were found to be expressed in various human normal and tumor tissues.
24975685 Overexpression of prostate RGN transgene in the prostate inhibits cell proliferation and apoptotic pathways.
24606440 SMP30 can inhibit the proliferation and invasion of human hepatoma cells and thus can be regarded as a cancer suppressive factor.
23453039 Regucalcin may be a key molecule in lipid metabolic disorder and diabetes--{review}
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AA Sequence

MSSIKIECVLPENCRCGESPVWEEVSNSLLFVDIPAKKVCRWDSFTKQVQRVTMDAPVSSVALRQSGGYV      1 - 70
ATIGTKFCALNWKEQSAVVLATVDNDKKNNRFNDGKVDPAGRYFAGTMAEETAPAVLERHQGALYSLFPD     71 - 140
HHVKKYFDQVDISNGLDWSLDHKIFYYIDSLSYSVDAFDYDLQTGQISNRRSVYKLEKEEQIPDGMCIDA    141 - 210
EGKLWVACYNGGRVIRLDPVTGKRLQTVKLPVDKTTSCCFGGKNYSEMYVTCARDGMDPEGLLRQPEAGG    211 - 280
IFKITGLGVKGIAPYSYAG                                                       281 - 299
//

Text Mined References (48)

PMID Year Title
26619319 2015 Expressions of Senescence-Associated ?-Galactosidase and Senescence Marker Protein-30 are Associated with Lens Epithelial Cell Apoptosis.
26171977 2015 Effect of extracellular calcium on regucalcin expression and cell viability in neoplastic and non-neoplastic human prostate cells.
26072307 2015 Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.
25847529 2015 Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
25230901 2015 Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy.
25128811 2015 Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis.
25050833 2014 Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues.
24975685 2014 Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways.
24606440 2014 Inhibition of SMP30 gene expression influences the biological characteristics of human Hep G2 cells.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
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