Property Summary

NCBI Gene PubMed Count 32
PubMed Score 34.43
PubTator Score 20.82

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Chloracne 32
Obesity 616
Osteoporosis 259
Disease Target Count P-value
malignant mesothelioma 3163 2.50566234259529E-7
posterior fossa group A ependymoma 1511 5.03633585266703E-7
tuberculosis and treatment for 3 months 327 7.16073377155292E-7
pilocytic astrocytoma 3086 1.89382233722488E-6
pediatric high grade glioma 2712 6.77915122325197E-6
atypical teratoid/rhabdoid tumor 1095 2.77274555632718E-4
ovarian cancer 8492 0.00149303927760524
glioblastoma 5572 0.00684369224764981
astrocytoma 1493 0.0169716114313554
subependymal giant cell astrocytoma 2287 0.0192104213266843
Rheumatoid Arthritis 1171 0.0294428796419263



Accession Q15404 A8KA46 D3DRU3 Q6FI17 RSP-1
Symbols RSP-1


  Ortholog (13)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly EggNOG Inparanoid

Gene RIF (8)

26170296 integrin/Rsu1/Rac1/actin signaling has a conserved role in modulating reward-related phenotypes, including ethanol consumption, across phyla
25750304 results showed that RSU-1 expression is elevated in HepG2 cells both at the mRNA and protein level
25647720 Upregulation of RSU1 is associated with metastatic breast cancer.
25482629 Rsu1 is required for EGF-induced activation of the p38 map kinase signaling
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
18436335 Rsu-1 links the Ras pathway with the IPP (integrin-linked kinase {ILK}, PINCH-1/LIMS1, parvin) complex and the perturbations of cell attachment-dependent signaling that occur in the malignant process
16385451 Observational study of gene-disease association. (HuGE Navigator)
12510772 alternative splicing of exon 8 of the RSU-1 RNA to produce the exon-deleted form constitutes a mechanism for reduction or loss of functional Rsu-1. The exon-deleted form was not found in normal tissue.

AA Sequence


Text Mined References (36)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26170296 2015 Rsu1 regulates ethanol consumption in Drosophila and humans.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25852190 2015 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
25750304 2015 Elimination of Ras Suppressor-1 from hepatocellular carcinoma cells hinders their in vitro metastatic properties.
25647720 2015 Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples.
25482629 2015 Rsu1 contributes to cell adhesion and spreading in MCF10A cells via effects on P38 map kinase signaling.
25416956 2014 A proteome-scale map of the human interactome network.
23793025 2013 Genome-wide meta-analysis identifies new susceptibility loci for migraine.
23455922 2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.