Property Summary

NCBI Gene PubMed Count 33
Grant Count 16
R01 Count 7
Funding $1,078,498.38
PubMed Score 43.07
PubTator Score 49.86

Knowledge Summary

Patent

No data available

Expression

Gene RIF (18)

PMID Text
25289861 Aurora-A/HURP relays cell transforming signal to NF-kappaB, and the HURP/NF-kappaB complex is engaged in the regulation of cyclin E1 expression.
24375315 Detection of urinary HURP RNA is a useful for early detection of bladder cancer and bilharzial bladder cancer.
24349376 expression of DLG7, a hypoxia-controlled gene, holds prognostic potential in high-risk CaP; this also demonstrates that variation of oxygen tension may constitute a tool for identification of novel biomarkers for CaP.
24324629 The expression of DLGAP5 is regulated by methylation; the up-regulation of DLGAP5 contributes to hepatocellular carcinoma tumorigenesis by promoting cell proliferation.
24183881 RNA purification using functionalized MNPs was 97%. CONCLUSIONS: The developed colorimetric HURP RNA AuNP assay is sensitive, simple, and can aid noninvasive diagnosis of bladder cancer
23610398 HURP is a substrate of Aurora kinase A, which plays a crucial role in the stabilization of kinetochore fiber
22230478 Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53.
22048964 DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT.
22022601 Hepatocellular carcinoma patients can be separated into three prognosis-distinguishable groups by use of a risk score that is based upon HURP expression.
21924616 HURP regulates Kif18A localization and dynamics at the plus end of kinetochore microtubules.
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AA Sequence

MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGL      1 - 70
VPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKA     71 - 140
EPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSAT    141 - 210
QAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSG    211 - 280
MNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEV    281 - 350
DESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE    351 - 420
GRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVD    421 - 490
DCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIAS    491 - 560
KPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSS    561 - 630
EGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLP    631 - 700
DLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEK    701 - 770
NTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSP    771 - 840
LQPGEF                                                                    841 - 846
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Text Mined References (43)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25289861 2015 The involvement of nuclear factor-?appaB in the nuclear targeting and cyclin E1 upregulating activities of hepatoma upregulated protein.
24375315 2014 Evaluation of urinary HURP mRNA as a marker for detection of bladder cancer: relation to bilharziasis.
24349376 2013 Prognostic value of discs large homolog 7 transcript levels in prostate cancer.
24324629 2013 Silencing of DLGAP5 by siRNA significantly inhibits the proliferation and invasion of hepatocellular carcinoma cells.
24183881 2014 Direct detection of unamplified hepatoma upregulated protein RNA in urine using gold nanoparticles for bladder cancer diagnosis.
23610398 2013 Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23056639 2012 A genome-wide association study of circulating galectin-3.
22230478 2012 Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53.
More...