Property Summary

NCBI Gene PubMed Count 35
PubMed Score 145.21
PubTator Score 88.48

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 1.20295732660494E-8
ovarian cancer 8492 5.83152757628963E-5
atypical teratoid / rhabdoid tumor 4369 1.16605075863025E-4
Multiple myeloma 1328 2.05627980341111E-4
psoriasis 6685 4.1952206382683E-4
glioblastoma 5572 6.01584887329092E-4
lung cancer 4473 0.0100510185969279
Disease Target Count Z-score Confidence
Perry syndrome 3 3.574 1.8
Parkinson's disease 364 3.068 1.5


  Differential Expression (7)

Disease log2 FC p
Multiple myeloma 2.245 0.000
psoriasis -1.300 0.000
posterior fossa group B ependymoma -1.300 0.000
atypical teratoid / rhabdoid tumor -1.100 0.000
glioblastoma -1.100 0.001
lung cancer 1.100 0.010
ovarian cancer -1.900 0.000


Accession Q15388 A8K195 Q498B3 Q6IBT4
Symbols MAS20


PANTHER Protein Class (1)



  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid

Gene RIF (6)

26615136 TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue.
23165776 Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells. In the inner ear of aged subjects with Meniere's disease, there was decreased expression of Tom20.
21771790 a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition
20877624 Observational study of gene-disease association. (HuGE Navigator)
14699115 the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface
11913975 Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins

AA Sequence

EDDVE                                                                     141 - 145

Text Mined References (49)

PMID Year Title
26615136 2015 Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.
25997101 2015 QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25764979 2015 The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.
25621951 2015 USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.
25327288 2014 Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
24896179 2014 The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23979707 2013 SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
23455425 2013 Autophagosomes form at ER-mitochondria contact sites.