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Tbio
ZMYND11
Zinc finger MYND domain-containing protein 11

Protein Summary
Description
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381591
  • ENSP00000371003
  • ENSG00000015171
  • ENST00000381607
  • ENSP00000371020
  • ENST00000397959
  • ENSP00000381050
  • ENST00000397962
  • ENSP00000381053
  • ENST00000509513
  • ENSP00000424205
  • ENST00000558098
  • ENSP00000452959
  • ENST00000602682
  • ENSP00000473321

Symbol
  • BRAM1
  • BS69
  • BS69
  • BRAM1
  • MRD30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
microRNA
0.96
disease perturbation
0.93
viral protein
0.93
virus perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.82   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.82   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0