| Tbio | Platelet-derived growth factor receptor-like protein |
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 4.9e-16 |
| malignant mesothelioma | 3232 | 3.2e-09 |
| Duchenne muscular dystrophy | 601 | 1.4e-07 |
| ovarian cancer | 8520 | 4.3e-07 |
| pituitary cancer | 1972 | 6.3e-07 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-06 |
| cystic fibrosis | 1696 | 5.7e-06 |
| non-small cell lung cancer | 2890 | 1.6e-05 |
| Atopic dermatitis | 952 | 1.7e-05 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 5.0e-04 |
| lung cancer | 4740 | 9.8e-04 |
| medulloblastoma, large-cell | 6241 | 9.8e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-03 |
| psoriasis | 6694 | 1.6e-03 |
| active Crohn's disease | 922 | 1.8e-03 |
| nasopharyngeal carcinoma | 1058 | 3.4e-03 |
| diabetes mellitus | 1728 | 6.0e-03 |
| cutaneous lupus erythematosus | 1057 | 1.7e-02 |
| invasive ductal carcinoma | 2951 | 2.2e-02 |
| ductal carcinoma in situ | 1745 | 2.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Perrault syndrome | 19 | 5.378 | 2.7 |
| Disease | Target Count |
|---|---|
| Carcinoma of colon | 32 |
| hepatocellular carcinoma | 547 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | 1.431 | 1.8e-03 |
| Atopic dermatitis | -2.900 | 1.7e-05 |
| breast carcinoma | -1.400 | 4.9e-16 |
| cutaneous lupus erythematosus | -1.300 | 1.7e-02 |
| cystic fibrosis | -1.439 | 5.7e-06 |
| diabetes mellitus | -1.300 | 6.0e-03 |
| Duchenne muscular dystrophy | 1.284 | 1.4e-07 |
| ductal carcinoma in situ | -1.500 | 2.2e-02 |
| intraductal papillary-mucinous adenoma (... | -3.000 | 1.1e-06 |
| intraductal papillary-mucinous carcinoma... | -2.100 | 1.1e-03 |
| intraductal papillary-mucinous neoplasm ... | -2.700 | 5.0e-04 |
| invasive ductal carcinoma | -2.000 | 2.2e-02 |
| lung cancer | -2.100 | 9.8e-04 |
| malignant mesothelioma | -3.200 | 3.2e-09 |
| medulloblastoma, large-cell | -1.100 | 9.8e-04 |
| nasopharyngeal carcinoma | 1.300 | 3.4e-03 |
| non-small cell lung cancer | 1.060 | 1.6e-05 |
| ovarian cancer | -2.800 | 4.3e-07 |
| pituitary cancer | -2.200 | 6.3e-07 |
| psoriasis | -1.400 | 1.6e-03 |
MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQ 1 - 70 VLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGE 71 - 140 FSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHRE 141 - 210 FPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASS 211 - 280 NKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETI 281 - 350 DAGYYICTAQNLQGQTTVATTVEFS 351 - 375 //
