Tbio PPP2R5B Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Protein Summary

Description

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15173
• Q13853

Gene Name

• PPP2R5B

Ensembl ID

• ENST00000164133
• ENSP00000164133
• ENSG00000068971

Symbol

• B56B
• PR61B
• B56beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.89
transcription factor binding site profile	0.8
histone modification site profile	0.73
virus perturbation	0.72
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase 2a 56 Kda Regulatory Subunit Beta Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0