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Tchem
PRKD1
Serine/threonine-protein kinase D1

Protein Summary
Description
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331968
  • ENSP00000333568
  • ENSG00000184304
  • ENST00000616995
  • ENSP00000482645

Symbol
  • PKD
  • PKD1
  • PRKCM
  • PKD
  • PKCM
  • CHDED
  • PRKCM
  • PKC-MU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
1
protein domain
1
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 977.79   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 873   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 977.79   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 873   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1