Property Summary

NCBI Gene PubMed Count 70
Grant Count 63
R01 Count 36
Funding $4,941,459.01
PubMed Score 101.03
PubTator Score 52.05

Knowledge Summary


No data available



Accession Q15121 B1AKZ3 O00511
Symbols PED



4IZ5   4IZA  

Gene RIF (53)

25957098 Latent HCMV infection of CD34 + cells protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.
25796184 Data show that phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) influences dephosphorylation of epidermal growth factor receptor (EGFR) via extracellular signal-regulated kinases ERK1/2 sequestration in the cytoplasm.
25775393 High PED expression is associated with esophageal carcinoma.
25725291 The nuclear translocation of SApErk1/ 2 apart from PEA-15 as an important mechanism to reverse senescence phenotype.
25489735 PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
25484138 Omi/HtrA2 overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 pro-apoptotic marker in the various hepatocellular carcinoma cell lines
25075716 Results suggest that neurochemical adaptations of brain FADD, as well as its interaction with PEA-15, could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression
24710276 Tumor suppressor PEA15 is a regulator of genome integrity and is an integral component of the DNA damage response pathway.
24657708 New therapeutic targets based around PEA-15 and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.
24477641 Up-regulated chaperone-mediated autophagy activity characteristic of most types of cancer cell enhances oncogenesis by shifting the balance of PED function toward tumor promotion.

AA Sequence


Text Mined References (78)

PMID Year Title
25957098 2015 Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA-15 pathway.
25796184 2015 PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells.
25775393 2015 Expression and significance of CDC25B, PED/PEA-15 in esophageal carcinoma.
25725291 2015 Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei.
25489735 2014 PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.
25484138 2015 Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
25075716 2014 FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments.
24710276 2014 PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.
24657708 2014 Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.
24477641 2014 Phosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.