Property Summary

NCBI Gene PubMed Count 36
PubMed Score 33.76
PubTator Score 22.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 4.94199197624259E-22
lung adenocarcinoma 2714 1.14767814203746E-10
posterior fossa group A ependymoma 1511 7.95238650671986E-10
juvenile dermatomyositis 1189 1.62356866560196E-8
pilocytic astrocytoma 3086 2.3908685665314E-6
pediatric high grade glioma 2712 1.37892900035675E-5
atypical teratoid/rhabdoid tumor 1095 1.46221247149024E-5
ovarian cancer 8492 1.30474731602797E-4
medulloblastoma, large-cell 6234 3.00082070952873E-4
sonic hedgehog group medulloblastoma 1482 7.12738889286873E-4
dermatomyositis 967 9.18216635224737E-4
glioblastoma 5572 0.00197962976936686
lung cancer 4473 0.00231500546840471
active Crohn's disease 918 0.00640224330742479
Multiple myeloma 1328 0.0143225944141874
inflammatory breast cancer 404 0.0229167790532721
pancreatic ductal adenocarcinoma liver metastasis 1795 0.023380720533545
invasive ductal carcinoma 2950 0.0265922361703692
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0461606496049717

Expression

Synonym

Accession Q15084 B3KY95 B5MCQ5 B7Z254 B7Z4M8 F8WA83 Q53RC7 Q6ZSH5 Q99778
Symbols P5
ERP5
TXNDC7

Gene

PDB

1X5D   3VWW   3W8J   4EF0   4GWR  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG
C. elegans OMA Inparanoid
Fruitfly OMA EggNOG Inparanoid

 MGI Term (1)

Gene RIF (22)

PMID Text
26676989 ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head.
26655997 Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
26125904 PDIA3 and PDIA6 gene expression is a neoplasm aggressiveness marker in primary ductal breast cancer.
24843047 Txnip is located in the endoplasmic reticulum and interacts with endogenous PDIA6. Txnip increases PDI activity.
24464223 CDDP-resistant non-small lung cancer cells undergo profound remodeling of their endoplasmic reticulum (ER) proteome (>80 proteins identified by proteomics) and exhibit a dramatic overexpression of two protein disulfide isomerases, PDIA4 and PDIA6.
23206338 PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells
22230366 PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells
22215138 levels of expression of ERp5 and GRP78 correlated with the level of expression of membrane-bound MICA in chronic lymphocytic leukemia patients.
22190034 PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells
22167753 Data show that the lymph node (LN) stroma displayed in situ high levels of transcription and expression of the disulfide-isomerase ERp5 and of the disintegrin-metalloproteinase ADAM10, able to shed the ligands for NKG2D (NKG2D-L) from the cell membrane.
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AA Sequence

MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAAT      1 - 70
ALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLG     71 - 140
GRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQ    141 - 210
TKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLE    211 - 280
IINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALG    281 - 350
IGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELP    351 - 420
VEDDIDLSDVELDDLGKDEL                                                      421 - 440
//

Text Mined References (50)

PMID Year Title
26676989 2016 Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.
26655997 2016 Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
26125904 2015 PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24843047 2014 Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.
24464223 2014 The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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