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Tbio
ARHGEF6
Rho guanine nucleotide exchange factor 6

Protein Summary
Description
Acts as a RAC1 guanine nucleotide exchange factor (GEF). Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250617
  • ENSP00000250617
  • ENSG00000129675
  • ENST00000370620
  • ENSP00000359654
  • ENST00000370622
  • ENSP00000359656

Symbol
  • COOL2
  • KIAA0006
  • PIXA
  • PIXA
  • COOL2
  • MRX46
  • Cool-2
  • alphaPIX
  • alpha-PIX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
protein domain
0.85
hub protein
0.79
kinase perturbation
0.71
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.39   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.39   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0