| Tchem | Lysine--tRNA ligase |
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 45 |
| NCBI Gene PubMed Count | 66 |
| PubMed Score | 282.49 |
| PubTator Score | 139.11 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE B | 1 | 0.0 | 0.0 |
| DEAFNESS, AUTOSOMAL RECESSIVE 89 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| sonic hedgehog group medulloblastoma | 467 | 1.8e-06 |
| psoriasis | 6694 | 7.2e-05 |
| medulloblastoma, large-cell | 6241 | 1.3e-04 |
| dermatomyositis | 966 | 7.2e-04 |
| Multiple myeloma | 1332 | 8.5e-04 |
| astrocytoma | 1146 | 1.8e-03 |
| diabetes mellitus | 1728 | 2.2e-03 |
| lung cancer | 4740 | 2.9e-03 |
| ovarian cancer | 8520 | 5.8e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 6.1e-03 |
| Waldenstrons macroglobulinemia | 765 | 1.9e-02 |
| acute myeloid leukemia | 783 | 2.7e-02 |
| Subcutaneous panniculitis-like T-cell lymphoma | 16 | 2.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Charcot-Marie-Tooth disease | 62 | 0.0 | 4.0 |
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Neuropathy | 261 | 0.0 | 4.0 |
| Nonsyndromic deafness | 142 | 0.0 | 4.0 |
| Disease | Target Count |
|---|---|
| Autosomal recessive nonsyndromic deafness 89 | 6 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.700 | 2.7e-02 |
| astrocytoma | 1.400 | 1.8e-03 |
| dermatomyositis | 1.400 | 7.2e-04 |
| diabetes mellitus | -1.500 | 2.2e-03 |
| lung cancer | 1.100 | 2.9e-03 |
| medulloblastoma, large-cell | 1.200 | 1.3e-04 |
| mucosa-associated lymphoid tissue lympho... | -1.009 | 6.1e-03 |
| Multiple myeloma | 1.226 | 8.5e-04 |
| ovarian cancer | -1.100 | 5.8e-03 |
| psoriasis | 1.400 | 7.2e-05 |
| sonic hedgehog group medulloblastoma | 1.100 | 1.8e-06 |
| Subcutaneous panniculitis-like T-cell ly... | 1.600 | 2.9e-02 |
| Waldenstrons macroglobulinemia | 1.001 | 1.9e-02 |
CHEMBL479820
pIC50 6.12
CHEMBL2178352
pIC50 6.14
CHEMBL511829
pIC50 6.16
CHEMBL2069334
pIC50 6.28
CHEMBL2069342
pIC50 6.35
CHEMBL509032
pIC50 6.54
CHEMBL482175
pIC50 6.64
CHEMBL1835870
pKi 6.66
CHEMBL2069336
pIC50 6.70
CHEMBL2069340
pIC50 6.80
CHEMBL476741
pIC50 6.82
CHEMBL475882
pIC50 6.92
CHEMBL2069343
pIC50 6.94
CHEMBL2069337
pIC50 7.04
CHEMBL478642
pIC50 7.08
CHEMBL2323631
pIC50 7.10
CHEMBL459850
pEC50 7.15
CHEMBL2323635
pIC50 7.15
CHEMBL2323632
pIC50 7.15
CHEMBL2323633
pIC50 7.19
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEES 1 - 70 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGG 71 - 140 KLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCL 141 - 210 HMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 211 - 280 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL 281 - 350 MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 351 - 420 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFV 421 - 490 MKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTD 491 - 560 SNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 561 - 597 //
