Tchem | Lysine--tRNA ligase |
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count |
---|---|
DEAFNESS, AUTOSOMAL RECESSIVE 89 | 1 |
Disease | Target Count | P-value |
---|---|---|
sonic hedgehog group medulloblastoma | 1482 | 1.84498397960978E-6 |
psoriasis | 6685 | 7.19218471656686E-5 |
medulloblastoma, large-cell | 6234 | 1.3385184711092E-4 |
ovarian cancer | 8492 | 1.7280747150131E-4 |
dermatomyositis | 967 | 7.21862478461171E-4 |
Multiple myeloma | 1328 | 8.48722555488116E-4 |
diabetes mellitus | 1663 | 0.00132043101235388 |
astrocytoma | 1493 | 0.00178355194745702 |
lung cancer | 4473 | 0.00285082688954372 |
mucosa-associated lymphoid tissue lymphoma | 480 | 0.00607487838360918 |
Waldenstrons macroglobulinemia | 765 | 0.0089495604529964 |
acute myeloid leukemia | 785 | 0.0267514481114973 |
Subcutaneous panniculitis-like T-cell lymphoma | 16 | 0.0286586595542237 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Charcot-Marie-Tooth disease | 74 | 0.0 | 4.0 |
Neurodegenerative disease | 383 | 0.0 | 4.0 |
Neuropathy | 210 | 0.0 | 4.0 |
Nonsyndromic deafness | 121 | 0.0 | 4.0 |
Disease | Target Count |
---|---|
Charcot-Marie-Tooth disease, recessive, intermediate type, B | 1 |
Deafness, autosomal recessive, 89 | 1 |
Disease | log2 FC | p |
---|---|---|
Waldenstrons macroglobulinemia | 1.549 | 0.009 |
Multiple myeloma | 1.226 | 0.001 |
psoriasis | 1.400 | 0.000 |
astrocytoma | 1.400 | 0.002 |
medulloblastoma, large-cell | 1.200 | 0.000 |
lung cancer | 1.100 | 0.003 |
diabetes mellitus | -1.600 | 0.001 |
sonic hedgehog group medulloblastoma | 1.100 | 0.000 |
Subcutaneous panniculitis-like T-cell ly... | 1.600 | 0.029 |
mucosa-associated lymphoid tissue lympho... | -1.009 | 0.006 |
acute myeloid leukemia | 1.700 | 0.027 |
ovarian cancer | 2.400 | 0.000 |
dermatomyositis | 1.400 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
C. elegans | OMA EggNOG Inparanoid |
S.cerevisiae | OMA EggNOG Inparanoid |
CHEMBL479820
pIC50 6.12
CHEMBL2178352
pIC50 6.14
CHEMBL511829
pIC50 6.16
CHEMBL2069334
pIC50 6.28
CHEMBL2069342
pIC50 6.35
CHEMBL509032
pIC50 6.54
CHEMBL482175
pIC50 6.64
CHEMBL1835870
pKi 6.66
CHEMBL2069336
pIC50 6.70
CHEMBL2069340
pIC50 6.80
CHEMBL476741
pIC50 6.82
CHEMBL475882
pIC50 6.92
CHEMBL2069343
pIC50 6.94
CHEMBL2069337
pIC50 7.04
CHEMBL478642
pIC50 7.08
CHEMBL2323631
pIC50 7.10
CHEMBL459850
pEC50 7.15
CHEMBL2323635
pIC50 7.15
CHEMBL2323632
pIC50 7.15
CHEMBL2323633
pIC50 7.19
PMID | Text |
---|---|
26643967 | finding show that enzymatically active Shiga toxins trigger the dissociation of lysyl-tRNA synthetase (KRS) from the multi-aminoacyl-tRNA synthetase complex in human macrophage-like differentiated THP-1 cells and its subsequent secretion. |
26091349 | KRS at the plasma membrane plays new roles in metastatic migration as a signaling inducer, and causes intracellular signaling for cancer dissemination |
25918939 | tRK1 forms a complex with human enolases and interacts with tRK1 and human pre-lysyl-tRNA synthetase (preKARS2) |
25010285 | Homodimeric lysyl-tRNA synthetase dissociates into a monomer that bridges between HIV-1 Gag and tRNA(Lys3) |
24983501 | structural characteristics of the KRS-LR interaction on the cell surface |
23972532 | Lysyl-tRNA synthetase plays essential role in HIV replication, transcriptional regulation, cytokine-like signaling. [review] |
23799079 | The role of preKARS2 in the tRNA mitochondrial import. |
23768514 | The KARS variant is identified in two families affected by DFNB89-associated autosomal-recessive nonsyndromic hearing impairment. |
23208549 | C-terminal domain of HIV-1 capsid protein as surrogate for human lysyl tRNA synthetase |
23208549 | Homodimeric lysyl-tRNA synthetase dissociates into a monomer that bridges between HIV-1 Gag and tRNA(Lys3) |
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MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEES 1 - 70 VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGG 71 - 140 KLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCL 141 - 210 HMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 211 - 280 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL 281 - 350 MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR 351 - 420 KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFV 421 - 490 MKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTD 491 - 560 SNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV 561 - 597 //
PMID | Year | Title |
---|---|---|
26643967 | 2016 | Shiga Toxins Trigger the Secretion of Lysyl-tRNA Synthetase to Enhance Proinflammatory Responses. |
26091349 | 2015 | Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. |
25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. |
25918939 | 2015 | A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
25086665 | 2014 | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. |
24983501 | 2014 | Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR. |
23972532 | 2013 | Non-canonical roles of lysyl-tRNA synthetase in health and disease. |
23799079 | 2013 | Induced tRNA import into human mitochondria: implication of a host aminoacyl-tRNA-synthetase. |
23768514 | 2013 | Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89. |
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