Tbio SLC39A14 Zinc transporter ZIP14

Protein Summary

Description

Broad-scope metal ion transporter with a preference for zinc uptake (PubMed:29621230). Also mediates cellular uptake of nontransferrin-bound iron. This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q15043
• A6NH98
• B4DIW3
• B6EU88
• D3DSR4
• Q6ZME8
• Q96BB3

Gene Name

• SLC39A14

Ensembl ID

• ENST00000240095
• ENSP00000240095
• ENSG00000104635
• ENST00000289952
• ENSP00000289952
• ENST00000359741
• ENSP00000352779
• ENST00000381237
• ENSP00000370635

Symbol

• KIAA0062
• ZIP14
• HCIN
• NET34
• ZIP14
• cig19
• HMNDYT2
• LZT-Hs4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
PubMedID	0.93
transcription factor binding site profile	0.9
virus perturbation	0.9
microRNA	0.83

Protein Classes

PANTHER Classes

Protein / Transporter / Zinc Transporter Zip14

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Zip14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.29   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.29   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0