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  5. Probable E3 ubiquitin-protein ligase HERC3

Tdark Probable E3 ubiquitin-protein ligase HERC3

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 4.43
PubTator Score 4.52

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Liver neoplasms 109
Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 2.12765026096009E-7
osteosarcoma 7933 2.57101485803681E-6
tuberculosis and treatment for 6 months 686 0.00174668356957262

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -1.317 0.000
atypical teratoid / rhabdoid tumor -1.200 0.000
tuberculosis and treatment for 6 months 1.100 0.002

Synonym

Accession Q15034 A8K1S5 Q8IXX3
Symbols

Gene

HERC3

PANTHER Protein Class (2)

  Ortholog (7)

Species Source
Macaque EggNOG Inparanoid
Mouse EggNOG Inparanoid
Rat EggNOG Inparanoid
Dog EggNOG Inparanoid
Horse EggNOG Inparanoid
Cow EggNOG Inparanoid
Pig EggNOG Inparanoid

 GO Function (1)

 GO Component (3)

 GO Process (1)

 Compartment GO Term (18)

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 IMPC Term (5)

 MGI Term (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (7)

 UniProt Keyword (10)

Gene RIF (3)

PMID Text
26476452 HERC3 negatively regulates NF-kappaB signaling by enhancing RelA subunit degradation.
22124266 we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

AA Sequence 

MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHER      1 - 70
EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTIL     71 - 140
QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA    141 - 210
VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN    211 - 280
DEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSG    281 - 350
QLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA    351 - 420
NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCL    421 - 490
IPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLV    491 - 560
NLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW    561 - 630
FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSP    631 - 700
FLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQ    701 - 770
DSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE    771 - 840
LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFS    841 - 910
SGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKF    911 - 980
LLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA    981 - 1050
//

Text Mined References (14)

PMID Year Title
26476452 2015 The ubiquitin ligase HERC3 attenuates NF-?B-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.
22124266 2011 Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15676274 2005 The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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