Tdark | Probable E3 ubiquitin-protein ligase HERC3 |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Comments
Disease | Target Count |
---|---|
Liver neoplasms | 109 |
Disease | Target Count | P-value |
---|---|---|
atypical teratoid / rhabdoid tumor | 4369 | 2.12765026096009E-7 |
osteosarcoma | 7933 | 2.57101485803681E-6 |
tuberculosis and treatment for 6 months | 686 | 0.00174668356957262 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -1.317 | 0.000 |
atypical teratoid / rhabdoid tumor | -1.200 | 0.000 |
tuberculosis and treatment for 6 months | 1.100 | 0.002 |
Species | Source |
---|---|
Macaque | EggNOG Inparanoid |
Mouse | EggNOG Inparanoid |
Rat | EggNOG Inparanoid |
Dog | EggNOG Inparanoid |
Horse | EggNOG Inparanoid |
Cow | EggNOG Inparanoid |
Pig | EggNOG Inparanoid |
PMID | Text |
---|---|
26476452 | HERC3 negatively regulates NF-kappaB signaling by enhancing RelA subunit degradation. |
22124266 | we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability |
20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHER 1 - 70 EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTIL 71 - 140 QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 141 - 210 VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN 211 - 280 DEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSG 281 - 350 QLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA 351 - 420 NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCL 421 - 490 IPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLV 491 - 560 NLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMW 561 - 630 FLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSP 631 - 700 FLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQ 701 - 770 DSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE 771 - 840 LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFS 841 - 910 SGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKF 911 - 980 LLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSLA 981 - 1050 //
PMID | Year | Title |
---|---|---|
26476452 | 2015 | The ubiquitin ligase HERC3 attenuates NF-?B-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. |
22124266 | 2011 | Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability. |
20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |
15676274 | 2005 | The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
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