Tbio ACAP1 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Protein Summary

Description

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.

Uniprot Accession IDs

• Q15027
• Q53XN9

Gene Name

• ACAP1

Ensembl ID

• ENST00000158762
• ENSP00000158762
• ENSG00000072818

Symbol

• CENTB1
• KIAA0050
• CENTB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
tissue sample	0.69
gene perturbation	0.62
cell type or tissue	0.58
hub protein	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.76   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.76   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0