Property Summary

NCBI Gene PubMed Count 24
Grant Count 1
R01 Count 1
Funding $113,666.67
PubMed Score 4.93
PubTator Score 3.10

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (3)

Expression

  Differential Expression (3)

Disease log2 FC p
Multiple myeloma 1.072 0.002
psoriasis -1.100 0.000
osteosarcoma -1.803 0.000

Synonym

Accession Q15024 Q96E72
Symbols p8
EAP1
RRP42
Rrp42p
hRrp42p

Gene

 Grant Application (1)

PDB

2NN6  

Gene RIF (4)

PMID Text
22174317 HIV-1 Rev interacting protein, exosome component 7 (EXOSC7), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
21509594 EXOSC7 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
12419256 Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
11812149 The association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p.

AA Sequence

MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPK      1 - 70
LEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVL     71 - 140
LLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRH    141 - 210
VVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESL    211 - 280
GPKRQKVGFLG                                                               281 - 291
//

Text Mined References (30)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25416956 2014 A proteome-scale map of the human interactome network.
24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21876179 2011 Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.
21509594 2011 Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
21269460 2011 Initial characterization of the human central proteome.
21255825 2011 The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
20531389 2010 Dis3-like 1: a novel exoribonuclease associated with the human exosome.
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