| Tchem | Calcium-activated chloride channel regulator 4 |
May be involved in mediating calcium-activated chloride conductance.
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3099 | 8.50137471674709E-70 |
| glioblastoma multiforme | 347 | 2.41302754471022E-8 |
| oligodendroglioma | 2849 | 1.32518262515803E-6 |
| non-small cell lung cancer | 2798 | 1.38176118392063E-4 |
| nasopharyngeal carcinoma | 1056 | 2.68171016757352E-4 |
| colon cancer | 1475 | 0.00143731222486441 |
| Down syndrome | 548 | 0.00334555414073675 |
| interstitial cystitis | 2299 | 0.00869865096827241 |
| chronic rhinosinusitis | 512 | 0.0115548020093655 |
| progressive supranuclear palsy | 674 | 0.0124025314012 |
| esophageal adenocarcinoma | 737 | 0.0228865400907423 |
| spina bifida | 1064 | 0.042747257413629 |
| ependymoma | 2514 | 0.0454226930575158 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| BESTROPHINOPATHY | 4 | 3.305 | 1.7 |
| Anhidrosis | 12 | 3.143 | 1.6 |
| Disease | Target Count |
|---|---|
| cystic fibrosis | 1670 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | 2.700 | 0.001 |
| ependymoma | -2.400 | 0.045 |
| esophageal adenocarcinoma | -4.100 | 0.023 |
| glioblastoma multiforme | -1.100 | 0.000 |
| oligodendroglioma | -1.100 | 0.000 |
| non-small cell lung cancer | 1.318 | 0.000 |
| colon cancer | -4.700 | 0.001 |
| interstitial cystitis | -4.100 | 0.009 |
| nasopharyngeal carcinoma | -2.900 | 0.000 |
| spina bifida | -1.391 | 0.043 |
| progressive supranuclear palsy | -1.800 | 0.012 |
| Breast cancer | -2.700 | 0.000 |
| Down syndrome | 1.100 | 0.003 |
| chronic rhinosinusitis | 1.869 | 0.012 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 24386311 | CLCA4 and CLCA2 play complementary but distinct roles in epithelial differentiation |
| 23073314 | CLCA4 modulates the capability to express residual chloride secretion in colonic tissue. |
| 19460752 | Knockdown of chloride channel accessory 4 (CLCA4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
| 15490240 | CLCA1 and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis |
| 10758170 | HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 |
MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKR 1 - 70 FFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLG 71 - 140 KKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRAC 141 - 210 RIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSE 211 - 280 DFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFD 281 - 350 STATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTAS 351 - 420 SCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQL 421 - 490 ESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTA 491 - 560 KVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVT 561 - 630 AFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAY 631 - 700 IPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKI 701 - 770 ILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATH 771 - 840 IFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVI 841 - 910 VNFILSTTI 911 - 919 //
| PMID | Year | Title |
|---|---|---|
| 24386311 | 2013 | Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 23073314 | 2013 | CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine. |
| 18254958 | 2008 | Transcriptomic dissection of tongue squamous cell carcinoma. |
| 16740002 | 2006 | Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| 16012037 | 2005 | Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps. |
| 15490240 | 2004 | The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| More... |
