| Tbio | Calcium-activated chloride channel regulator 4 |
May be involved in mediating calcium-activated chloride conductance.
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 8.5e-70 |
| glioblastoma multiforme | 142 | 2.4e-08 |
| oligodendroglioma | 2850 | 1.3e-06 |
| non-small cell lung cancer | 2890 | 1.4e-04 |
| nasopharyngeal carcinoma | 1058 | 2.7e-04 |
| Down syndrome | 499 | 3.3e-03 |
| colon cancer | 1478 | 6.2e-03 |
| interstitial cystitis | 2312 | 8.7e-03 |
| chronic rhinosinusitis | 512 | 1.2e-02 |
| progressive supranuclear palsy | 676 | 1.2e-02 |
| esophageal adenocarcinoma | 737 | 2.3e-02 |
| spina bifida | 1074 | 4.3e-02 |
| ependymoma | 4679 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hereditary spherocytosis type 2 | 18 | 3.332 | 1.7 |
| Bestrophinopathy | 3 | 3.154 | 1.6 |
| Hereditary spherocytosis type 4 | 18 | 3.109 | 1.6 |
| Anhidrosis | 23 | 3.073 | 1.5 |
| Disease | Target Count |
|---|---|
| cystic fibrosis | 1696 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | 2.700 | 1.2e-03 |
| Breast cancer | -2.700 | 8.5e-70 |
| chronic rhinosinusitis | 1.869 | 1.2e-02 |
| colon cancer | -2.400 | 6.2e-03 |
| Down syndrome | 1.100 | 3.3e-03 |
| ependymoma | -2.400 | 4.5e-02 |
| esophageal adenocarcinoma | -4.100 | 2.3e-02 |
| glioblastoma multiforme | -1.100 | 2.4e-08 |
| interstitial cystitis | -4.100 | 8.7e-03 |
| nasopharyngeal carcinoma | -2.900 | 2.7e-04 |
| non-small cell lung cancer | 1.318 | 1.4e-04 |
| oligodendroglioma | -1.100 | 1.3e-06 |
| progressive supranuclear palsy | -1.800 | 1.2e-02 |
| spina bifida | -1.391 | 4.3e-02 |
MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKR 1 - 70 FFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLG 71 - 140 KKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRAC 141 - 210 RIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSE 211 - 280 DFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFD 281 - 350 STATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTAS 351 - 420 SCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQL 421 - 490 ESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTA 491 - 560 KVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVT 561 - 630 AFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAY 631 - 700 IPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKI 701 - 770 ILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATH 771 - 840 IFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVI 841 - 910 VNFILSTTI 911 - 919 //
