Tbio ARHGAP19 Rho GTPase-activating protein 19

Protein Summary

Description

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q14CB8
• A1XCP1
• B4DZR1
• Q14CF2
• Q5J8M2
• Q5T460
• Q5T462
• Q68DG6
• Q8N9X1
• Q8NF34
• Q8TEK1

Gene Name

• ARHGAP19

Ensembl ID

• ENST00000358308
• ENSP00000351058
• ENSG00000213390
• ENST00000358531
• ENSP00000351333
• ENST00000371027
• ENSP00000360066

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
microRNA	0.78
histone modification site profile	0.74
kinase perturbation	0.71
transcription factor binding site profile	0.69

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 19

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 19

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0