Property Summary

NCBI Gene PubMed Count 24
PubMed Score 18.42
PubTator Score 10.18

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count
Brugada Syndrome (disorder) 15
Disease Target Count P-value
Breast cancer 3099 3.59601570967091E-13
ovarian cancer 8492 2.71301322194225E-6
glioblastoma 5572 1.87078220045534E-5
medulloblastoma 1524 2.58807173058989E-5
tuberculosis and treatment for 6 months 686 2.62013852072102E-5
medulloblastoma, large-cell 6234 2.58329798947455E-4
atypical teratoid / rhabdoid tumor 4369 4.74474096103107E-4
primitive neuroectodermal tumor 3031 9.07865711701839E-4
primary pancreatic ductal adenocarcinoma 1271 0.00248660916680066
osteosarcoma 7933 0.00378298300115946
hereditary spastic paraplegia 313 0.00508918026835871
pancreatic cancer 2300 0.00646435391273092
Rheumatoid Arthritis 1171 0.0213438498818576
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0342823026686893
aldosterone-producing adenoma 664 0.0345289265391427
spina bifida 1064 0.04349419738882
Disease Target Count Z-score Confidence
ulcerative colitis 2087 0.0 2.0
Disease Target Count Z-score Confidence
Duchenne muscular dystrophy 602 3.423 1.7
Leiomyosarcoma 19 3.177 1.6
Disease Target Count
Brugada syndrome 26

Expression

Gene

PANTHER Protein Class (1)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

 GO Process (1)

 GWAS Trait (1)

Pathway (1)

Gene RIF (2)

PMID Text
25880194 The data suggests the potential role of SLMAP single nucleotide polymorphism as a risk factor for the susceptibility of diabetic retinopathy among type 2 diabetes patients in the Qatari population.
23064965 Mutations in SLMAP may cause Brugada syndrome via modulating the intracellular trafficking of hNav1.5 channel.

AA Sequence

MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQ      1 - 70
DTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSD     71 - 140
VIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDE    141 - 210
DRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLS    211 - 280
NTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEME    281 - 350
EKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQKKLI    351 - 420
VEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQ    421 - 490
SEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTE    491 - 560
NLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEI    561 - 630
TSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQ    631 - 700
SLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEM    701 - 770
TEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGLARASP                771 - 828
//

Text Mined References (28)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25880194 2015 Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population.
25416956 2014 A proteome-scale map of the human interactome network.
24366813 2013 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
24255178 2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
23455922 2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
23414517 2013 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
23386615 2013 The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
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