Property Summary

NCBI Gene PubMed Count 39
Grant Count 73
R01 Count 40
Funding $6,370,688.5
PubMed Score 145.39
PubTator Score 57.01

Knowledge Summary

Patent (5,328)

Expression

  Differential Expression (9)

Synonym

Accession Q14957 B2RTT1 GluN2C
Symbols NR2C
GluN2C
NMDAR2C

Gene

Gene RIF (55)

PMID Text
26289945 Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
26229101 these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface
25788577 NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.
25760043 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
25613138 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24925192 The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C.
24739951 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24102971 TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers
24086760 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23665428 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
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AA Sequence

MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVN      1 - 70
TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFL     71 - 140
QLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRA    141 - 210
RTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTES    211 - 280
WRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPG    281 - 350
GYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD    351 - 420
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV    421 - 490
WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMF    491 - 560
VMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL    561 - 630
VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH    631 - 700
THMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK    701 - 770
RAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY    771 - 840
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVS    841 - 910
SSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGR    911 - 980
PPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELE    981 - 1050
DLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQA   1051 - 1120
QSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGR   1121 - 1190
TLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV                              1191 - 1233
//

Text Mined References (42)

PMID Year Title
26289945 2015 The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving.
26229101 2015 Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking.
25788577 2015 Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.
24925192 2014 Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.
24102971 2013 Psoriatic keratinocytes are resistant to tumor necrosis factor alpha's induction of mRNA for the NMDA-R2C subunit.
23070074 2013 Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia.
22833210 2011 Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
22343826 2013 Diversity in NMDA receptor composition: many regulators, many consequences.
22245680 2012 Influence of the intracellular GluN2 C-terminal domain on NMDA receptor function.
22197913 2012 Molecular pharmacology of human NMDA receptors.
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