Tchem SLC9A5 Sodium/hydrogen exchanger 5

Protein Summary

Description

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity).

Uniprot Accession IDs

• Q14940
• A5PKY7
• Q9Y626

Gene Name

• SLC9A5

Ensembl ID

• ENST00000299798
• ENSP00000299798
• ENSG00000135740

Symbol

• NHE5
• NHE5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.7
transcription factor binding site profile	0.66
transcription factor	0.63
cell line	0.58
protein domain	0.58

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc9 Family Of Sodium/hydrogen Exchangers / Sodium/hydrogen Exchanger 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.21   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.21   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1