| Tbio | Nuclear factor 1 X-type |
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Marshall-Smith syndrome | 5 | 6.667 | 3.3 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.4e-18 |
| lung adenocarcinoma | 2716 | 4.7e-10 |
| malignant mesothelioma | 3232 | 5.3e-06 |
| Breast cancer | 3578 | 6.8e-06 |
| invasive ductal carcinoma | 2951 | 7.0e-04 |
| breast carcinoma | 1638 | 1.0e-03 |
| pituitary cancer | 1972 | 2.4e-03 |
| oligodendroglioma | 2850 | 3.7e-03 |
| psoriasis | 6694 | 5.5e-03 |
| ependymoma | 4679 | 6.0e-03 |
| group 4 medulloblastoma | 1855 | 8.0e-03 |
| osteosarcoma | 7950 | 1.1e-02 |
| ductal carcinoma in situ | 1745 | 1.1e-02 |
| acute myeloid leukemia | 783 | 3.0e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 3.0e-02 |
| astrocytic glioma | 2597 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chromosome 19p13.13 deletion syndrome | 5 | 0.0 | 5.0 |
| Disease | Target Count |
|---|---|
| Malan overgrowth syndrome | 1 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.100 | 3.0e-02 |
| astrocytic glioma | 1.100 | 3.0e-02 |
| Breast cancer | -1.100 | 6.8e-06 |
| breast carcinoma | -1.100 | 1.0e-03 |
| ductal carcinoma in situ | -1.300 | 1.1e-02 |
| ependymoma | 1.300 | 6.0e-03 |
| group 4 medulloblastoma | 1.300 | 8.0e-03 |
| invasive ductal carcinoma | -2.800 | 7.0e-04 |
| lung adenocarcinoma | -1.100 | 4.7e-10 |
| lung carcinoma | -1.700 | 2.4e-18 |
| malignant mesothelioma | -1.400 | 5.3e-06 |
| oligodendroglioma | 1.600 | 3.7e-03 |
| osteosarcoma | -1.207 | 1.1e-02 |
| pituitary cancer | -1.400 | 2.4e-03 |
| primary pancreatic ductal adenocarcinoma | 1.001 | 3.0e-02 |
| psoriasis | -2.400 | 5.5e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQK 1 - 70 WASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGI 71 - 140 PLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHL 141 - 210 SFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKS 211 - 280 IDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHP 281 - 350 LPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPN 351 - 420 GSGQGKVPGSFLLPPPPPVARPVPLPMPDSKSTSTAPDGAALTPPSPSFATTGASSANRFVSIGPRDGNF 421 - 490 LNIPQQSQSWFL 491 - 502 //
