Property Summary

NCBI Gene PubMed Count 57
PubMed Score 46.38
PubTator Score 48.39

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (6)

Disease Target Count P-value
juvenile dermatomyositis 1189 1.44542430978608E-8
pituitary cancer 1972 1.38728351738434E-7
malignant mesothelioma 3163 3.43500463378773E-7
cystic fibrosis 1670 5.77771620068629E-6
medulloblastoma, large-cell 6234 3.44715074325932E-5
breast carcinoma 1614 8.31451010600118E-5
acute quadriplegic myopathy 1157 1.51790029443616E-4
posterior fossa group B ependymoma 1530 3.8348811474105E-4
sonic hedgehog group medulloblastoma 1482 4.62482774707564E-4
pancreatic cancer 2300 6.4788431730261E-4
lung cancer 4473 8.69943773117423E-4
ovarian cancer 8492 0.00117915391838807
primary pancreatic ductal adenocarcinoma 1271 0.00165739605061544
invasive ductal carcinoma 2950 0.00244615266610809
ulcerative colitis 2087 0.0125325429906498
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0210019858971951
dermatomyositis 967 0.0234243017020634
Breast cancer 3099 0.0264115987989848
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0421820356189943
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
acute lymphocytic leukemia 25 4.761 2.4
Childhood leukemia 3 3.744 1.9
Disease Target Count
Leukemia, acute lymphoblastic 1

Expression

Gene

PDB

1IG6   2OEH  

  Ortholog (11)

Species Source
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

 GO Component (2)

Gene RIF (33)

PMID Text
26104880 Non-coding variant rs10821936 in ARID5B was strongly associated with childhood B-cell acute lymphoblastic leukemia. No coding variants were associated with B-ALL susceptibility.
25806972 Interactions between rs10740055 in ARID5B or rs4132601 in IKZF1 and each of the suspected non-genetic factors were tested.
25761407 variants within IKZF1, ARID5B, and CEBPE were associated with increased acute lymphoblastic leukemia (ALL) risk, and the effects for ARID5B and CEBPE were most prominent in high-hyperdiploid ALL subtype in the California Hispanic population
25310577 These results evidence that interaction of genetic variants in ARID5B and IKZF1 and environmental exposures may further alter risk of childhood acute lymphoblastic leukemia.
25005032 Data indicate no significant associations of transcription factors rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) with risk of pediatric non-Hodgkin lymphoma (NHL).
24712521 Our findings confirm the association of novel genetic variations in folate-related and ARID5B genes with the serum MTX levels and acute toxicity.
24564228 ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia.
24561991 In an epigenome-wide methylation Norwegian Mother-Baby cohort study 2 ARID5B CpGs were identified in cord blood DNA as having an inverse association with birth weight (higher methylation fraction associated with lower birth weight).
24497567 Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group.
24200646 We found that rs7073837 in ARID5B correlated with a risk for childhood B lineage ALL.
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AA Sequence

MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLL      1 - 70
SSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQK     71 - 140
EALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALAL    141 - 210
GGIAVVSRNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAV    211 - 280
AKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQI    281 - 350
NLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPI    351 - 420
KPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPA    421 - 490
ADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGAS    491 - 560
KQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKV    561 - 630
DQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVS    631 - 700
GASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTIN    701 - 770
DIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSL    771 - 840
YRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSL    841 - 910
PKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESLSRSGKPHH    911 - 980
VRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQE    981 - 1050
SEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLA   1051 - 1120
FHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL     1121 - 1188
//

Text Mined References (65)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26104880 2015 Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children.
25806972 2015 ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25761407 2015 Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children.
25755297 2015 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
25310577 2014 Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
25005032 2015 Childhood acute lymphoblastic leukemia-associated risk-loci IKZF1, ARID5B and CEBPE and risk of pediatric non-Hodgkin lymphoma: a report from the Berlin-Frankfurt-Münster Study Group.
24751813 2014 Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment.
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