Tchem CHD4 Chromodomain-helicase-DNA-binding protein 4

Protein Summary

Description

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q14839
• Q8IXZ5
• CHD-4

Gene Name

• CHD4

Ensembl ID

• ENST00000544040
• ENSP00000440542
• ENSG00000111642
• ENST00000645095
• ENSP00000496634

Symbol

• CHD-4
• Mi-2b
• SIHIWES
• Mi2-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	1
drug perturbation	0.99
disease perturbation	0.98
protein complex	0.98

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.17   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 306   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.17   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0