Property Summary

NCBI Gene PubMed Count 49
PubMed Score 1003.75
PubTator Score 268.86

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
HEM dysplasia 1
Reynold's syndrome 1
Disease Target Count P-value
astrocytoma 1493 1.2201591471448E-21
oligodendroglioma 2849 4.78698133587021E-14
juvenile dermatomyositis 1189 5.14607818919551E-11
posterior fossa group A ependymoma 1511 4.31354797430518E-10
glioblastoma 5572 1.79069118614086E-8
pilocytic astrocytoma 3086 1.31927713341384E-6
osteosarcoma 7933 2.64106110573228E-6
Breast cancer 3099 3.68662452385916E-6
primitive neuroectodermal tumor 3031 5.33891968707143E-6
pediatric high grade glioma 2712 6.06426864123416E-6
acute quadriplegic myopathy 1157 6.97811792002985E-6
group 3 medulloblastoma 2254 9.2927950867823E-6
medulloblastoma, large-cell 6234 1.65775094500737E-5
atypical teratoid/rhabdoid tumor 1095 7.19193573955458E-5
dermatomyositis 967 1.36485729380884E-4
primary Sjogren syndrome 789 0.00248288256154939
lung cancer 4473 0.0037121302023968
Waldenstrons macroglobulinemia 765 0.00643971600685061
chronic lymphocytic leukemia 244 0.00814759187172887
gastric carcinoma 832 0.0239535383010059
ovarian cancer 8492 0.0425650646852125

Expression

  Differential Expression (21)

Synonym

Accession Q14739 B2R5P3 Q14740 Q53GU7 Q59FE6
Symbols PHA
LMN2R
TDRD18
DHCR14B

Gene

LBR

PANTHER Protein Class (2)

PDB

2DIG  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid

 GWAS Trait (1)

Gene RIF (20)

PMID Text
24293108 Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 vs. NPI3 - 0.00 vs. 0.00; p = 0.0551).
23824842 Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype.
22581323 Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation.
21795390 Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor
21327094 The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C during in vitro granulopoiesis induced with retinoic acid.
21327084 LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly
21326950 a highly significant gene-dosage effect between the gene copy number and the nuclear segmentation index of neutrophils
21103616 LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20576617 LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis
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AA Sequence

MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSS      1 - 70
SPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIE     71 - 140
RNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFG    141 - 210
GVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKV    211 - 280
VEGTPLIDGRRLKYRLNGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLK    281 - 350
APRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM    351 - 420
ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLI    421 - 490
IVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSL    491 - 560
PCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY                   561 - 615
//

Text Mined References (59)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24293108 2013 The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23824842 2013 Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR.
23382691 2013 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22581323 2012 Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation.
21795390 2011 Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
More...