Property Summary

NCBI Gene PubMed Count 15
PubMed Score 5.13
PubTator Score 6.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 3.31260887341045E-19
non-small cell lung cancer 2798 4.88699760791646E-17
Breast cancer 3099 1.57767302383851E-7
malignant mesothelioma 3163 3.17891376575309E-7
chronic lymphosyte leukemia 232 1.88314402270336E-6
ovarian cancer 8492 8.77554752285501E-6
ulcerative colitis 2087 9.14669752744987E-6
sarcoidosis 368 1.52076020749305E-5
lung adenocarcinoma 2714 1.58729039125087E-5
medulloblastoma, large-cell 6234 3.86664561216976E-5
lung cancer 4473 5.08331637259931E-5
primary pancreatic ductal adenocarcinoma 1271 8.51769590033984E-5
medulloblastoma 1524 1.05793541733893E-4
primary Sjogren syndrome 789 1.35795847445949E-4
pancreatic cancer 2300 3.13086519220038E-4
cystic fibrosis 1670 3.84540650912803E-4
interstitial cystitis 2299 7.26993189563237E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00653420094211968
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00682601720514692
invasive ductal carcinoma 2950 0.00918194832180024
gastric carcinoma 832 0.0132325079737081
adrenocortical carcinoma 1427 0.0190536186387129
fibroadenoma 557 0.0214283748392424
ductal carcinoma in situ 1745 0.0235160645809784
subependymal giant cell astrocytoma 2287 0.0238873814890954
Waldenstrons macroglobulinemia 765 0.0339443680601565
atypical teratoid / rhabdoid tumor 4369 0.0467821378373468
Disease Target Count Z-score Confidence
Eye and adnexa disease 11 0.0 2.0

Expression

Synonym

Accession Q14699 Q0D2G0 Q496Y2 Q4QQI7 Q5JB48 Q7Z7P2
Symbols MIG2
PIG9
PIB10
RAFTLIN

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG

 GO Function (1)

Pathway (1)

Gene RIF (6)

PMID Text
23645746 Mitogen-inducible Gene-2 expression is reduced in breast cancer.
22222511 combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma.
21266579 Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19834535 Observational study of gene-disease association. (HuGE Navigator)
12805216 These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating B-cell antigen receptor-mediated signaling.

AA Sequence

MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLASLRDLPAQLL      1 - 70
ELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNEGYILELDCCSSLDHPTDQKL     71 - 140
IPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVSTANSTEDARDAKNARGDHASLENEKPGTGDV    141 - 210
CSAPAGRNQSPEPSSGPRGEVPLAKQPSSPSGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIF    211 - 280
TLFNKPKSHQKCRQYYPVTIPLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLT    281 - 350
DGVFIFEAVSTEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGS    351 - 420
VSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKNLEDQSSKAGD    421 - 490
MGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGPASHSRALVGICTGHSNPGED    491 - 560
ARDGDAEEVRELGTVEEN                                                        561 - 578
//

Text Mined References (20)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23645746 2013 Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer.
22222511 2012 Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma.
21955986 2011 Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21266579 2011 Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
20395239 2010 Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
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