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Tbio
ZNF268
Zinc finger protein 268

Protein Summary
Description
Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228289
  • ENSP00000228289
  • ENSG00000090612
  • ENST00000536435
  • ENSP00000444412
  • ENST00000539248
  • ENSP00000467781
  • ENST00000588312
  • ENSP00000466622

Symbol
  • HZF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
tissue
0.63
tissue sample
0.63
microRNA
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.86   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.86   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0