| Tbio | ELAV-like protein 3 |
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance.
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.6e-44 |
| juvenile dermatomyositis | 1187 | 4.0e-07 |
| ovarian cancer | 8520 | 4.4e-07 |
| ependymoma | 4679 | 3.1e-05 |
| psoriasis | 6694 | 5.3e-04 |
| group 3 medulloblastoma | 4104 | 1.2e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-03 |
| adult high grade glioma | 3801 | 2.4e-03 |
| glioblastoma | 5792 | 5.5e-03 |
| Astrocytoma, Pilocytic | 3081 | 8.2e-03 |
| subependymal giant cell astrocytoma | 2287 | 9.3e-03 |
| facioscapulohumeral dystrophy | 288 | 1.1e-02 |
| pituitary cancer | 1972 | 1.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Urinary bladder cancer | 36 | 4.935 | 2.5 |
| Neurodegenerative disease | 414 | 3.312 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.400 | 2.4e-03 |
| Astrocytoma, Pilocytic | -1.200 | 8.2e-03 |
| atypical teratoid / rhabdoid tumor | -2.700 | 2.0e-03 |
| ependymoma | -2.600 | 3.1e-05 |
| facioscapulohumeral dystrophy | 2.200 | 1.1e-02 |
| glioblastoma | -1.500 | 5.5e-03 |
| group 3 medulloblastoma | -2.500 | 1.2e-03 |
| juvenile dermatomyositis | -1.111 | 4.0e-07 |
| lung carcinoma | 2.700 | 1.6e-44 |
| ovarian cancer | -1.600 | 4.4e-07 |
| pituitary cancer | -1.500 | 1.8e-02 |
| psoriasis | 1.100 | 5.3e-04 |
| subependymal giant cell astrocytoma | -3.945 | 9.3e-03 |
MVTQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKL 1 - 70 VRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKE 71 - 140 MEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKT 141 - 210 GQALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAA 211 - 280 GAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRL 281 - 350 GERVLQVSFKTSKQHKA 351 - 367 //
