Property Summary

NCBI Gene PubMed Count 108
Grant Count 188
R01 Count 124
Funding $24,621,245.59
PubMed Score 501.03
PubTator Score 210.60

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
malignant mesothelioma -3.800 0.000
group 3 medulloblastoma 3.100 0.000
lung cancer 3.300 0.000
colon cancer -1.800 0.024
atypical teratoid/rhabdoid tumor 1.400 0.008
pilocytic astrocytoma 1.300 0.004
lung carcinoma -1.700 0.000

Synonym

Accession Q14563
Symbols HH16
SemD
COLL1
SEMA1
SEMAD
SEMAL
coll-1
Hsema-I
SEMAIII
Hsema-III

Gene

Gene RIF (86)

PMID Text
26602825 Semaphorin-3a, neuropilin-1 and plexin-A1 are axonal guidance molecules that have been recently implicated in regulating bone metabolism.
26432853 Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS.
26201903 Findings show the involvement of amphiregulin and semaphorin-3A in the improvement of skin innervations and penetration of nerve fibers into the epidermis.
26121211 LL-37 induces SeMA3A expression in epidermal keratinocytes. Possible therapy for pruritus in atopic dermatitis.
25973043 our data suggest that MCF-7 cell-derived Sema 3A plays a causative role in osteoblastic bone metastases progression by stimulating osteoblastic differentiation.
25955818 Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.
25895648 Sema3A expression is low in systemic sclerosis serum and more specifically on regulatory T cells.
25812535 Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma
25666438 Genetic risk for Hirschsprung disease in individuals of European ancestry can only be detected at RET (rs2435357 and rs2506030) and at SEMA3 (rs11766001), but not at NRG1.
25651171 Vital roles for semaphorin signaling in vascular patterning and cardiac morphogenesis have been demonstrated, and impaired semaphorin signaling has been associated with various human cardiovascular disorders.
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AA Sequence

MGWLTRIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLY      1 - 70
VGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPI     71 - 140
CTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHP    141 - 210
IRTEQHDSRWLNDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLV    211 - 280
NKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNIFKGSAVCMYSMSDVRR    281 - 350
VFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRP    351 - 420
IVIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAIS    421 - 490
AMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKRRTRRQDIRN    491 - 560
GDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRT    561 - 630
DQGLLLRSLQQKDSGNYLCHAVEHGFIQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSNSMTPSQK    631 - 700
VWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHTPGNSNKWKHLQENKKGRNRRTHEFERAPRS    701 - 770
V//

Text Mined References (111)

PMID Year Title
26602825 2016 Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss.
26432853 2015 Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.
26201903 2015 Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.
26121211 2015 Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to Pruritus.
25973043 2015 Breast cancer cells promote osteoblastic differentiation via Sema 3A signaling pathway in vitro.
25955818 2015 The Role Of Semaphorin 3A In The Skeletal System.
25895648 2015 Semaphorin 3A: an immunoregulator in systemic sclerosis.
25812535 2015 Decreased semaphorin 3A expression is associated with a poor prognosis in patients with epithelial ovarian carcinoma.
25666438 2015 Population variation in total genetic risk of Hirschsprung disease from common RET, SEMA3 and NRG1 susceptibility polymorphisms.
25651171 2015 Semaphorin signaling in cardiovascular development.
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