Tclin SCN5A Sodium channel protein type 5 subunit alpha

Protein Summary

Description

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138). The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14524
• A5H1P8
• A6N922
• A6N923
• B2RTU0
• E7ET19
• E9PEF3
• E9PEK2
• E9PFW7
• Q59H93
• Q75RX9
• Q75RY0
• Q86UR3
• Q8IZC9
• Q96J69

Gene Name

• SCN5A

Ensembl ID

• ENST00000333535
• ENSP00000328968
• ENSG00000183873
• ENST00000423572
• ENSP00000398266

Symbol

• HB1
• HB2
• HH1
• IVF
• VF1
• HBBD
• ICCD
• LQT3
• SSS1
• CDCD2
• CMD1E
• CMPD2
• PFHB1
• Nav1.5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
drug	0.95
protein domain	0.92
biological process	0.84
biological term	0.83

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 5 Subunit Alpha

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 5 Subunit Alpha

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 5 Subunit Alpha

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 5 Subunit Alpha

DTO Classes

Protein / Ion Channel / Sodium Channel Family / Nav1.5/scn5a Subfamily / Sodium Channel Protein Type 5 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2507.31   (req: < 5)

Gene RIFs: 592   (req: <= 3)

Antibodies: 295   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2507.31   (req: >= 5)

Gene RIFs: 592   (req: > 3)

Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 670

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 47