Tbio HES1 Transcription factor HES-1

Protein Summary

Description

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14469
• Q6FHB2

Gene Name

• HES1

Ensembl ID

• ENST00000232424
• ENSP00000232424
• ENSG00000114315

Symbol

• BHLHB39
• HL
• HRY
• HHL
• HRY
• HES-1
• bHLHb39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
virus perturbation	1
transcription factor binding site profile	0.99
PubMedID	0.97
transcription factor	0.91

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Transcription Factor Hes-1

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Factor Hes-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.32   (req: < 5)

Gene RIFs: 156   (req: <= 3)

Antibodies: 568   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.32   (req: >= 5)

Gene RIFs: 156   (req: > 3)

Antibodies: 568   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 87

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0