Property Summary

NCBI Gene PubMed Count 38
Grant Count 179
R01 Count 102
Funding $25,518,445.62
PubMed Score 574.88
PubTator Score 35.42

Knowledge Summary

Patent (42,401)

Expression

  Differential Expression (6)

Synonym

Accession Q14416 B0M0K7 Q14CU5 Q52MC6 Q9H3N6 mGluR2
Symbols GLUR2
mGlu2
GPRC1B
MGLUR2

Gene

PANTHER Protein Class (2)

PDB

4XAQ   4XAS   5CNI   5CNJ  

  TechDev Info (1)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
743433 confirmatory 0 / 0 / 1 Selectivity Studies of mglur8 probe at mglur2

Gene RIF (33)

PMID Text
26758213 Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
26589404 this work offers new insights into the functioning of the mGlu2 receptor, which might contribute to the development of new and improved PAMs
25571949 Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.
25150943 Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density
24949866 Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia
23407939 Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects
23149219 the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls.
23129762 Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.
22988116 Only full-length dimeric mGlu2 activates G protein upon glutamate binding.
22870276 the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.
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AA Sequence

MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALD      1 - 70
RINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVI     71 - 140
GGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTV    141 - 210
ASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLA    211 - 280
ASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWE    281 - 350
QRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK    351 - 420
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASP    421 - 490
SAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEY    491 - 560
IRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTA    561 - 630
VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVV    631 - 700
EAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTC    701 - 770
IIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA    771 - 840
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL                                          841 - 872
//

Text Mined References (39)

PMID Year Title
26758213 2016 Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
26589404 2016 Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
25571949 2015 Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.
25416956 2014 A proteome-scale map of the human interactome network.
25150943 2014 Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
24949866 2014 Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.
24080311 2014 Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.
23407939 2013 Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.
23149219 2013 Evaluation of hypermethylation and expression pattern of GMR2, GMR5, GMR8, and GRIA3 in patients with schizophrenia.
23129762 2012 Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function.
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