Property Summary

NCBI Gene PubMed Count 28
Grant Count 4
R01 Count 1
Funding $391,730.81
PubMed Score 24.97
PubTator Score 53.18

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q14392 Q86V06
Symbols GARP
D11S833E

Gene

PANTHER Protein Class (1)

Gene RIF (14)

PMID Text
26584734 since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb
26357016 GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
24098777 GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells.
23650616 we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells
22278742 Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation.
22070912 There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels
21907864 on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk
21615933 the processing and expression of LRRC32
20237496 Observational study of gene-disease association. (HuGE Navigator)
19750484 Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones.
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AA Sequence

MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLG      1 - 70
FYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGL     71 - 140
LERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT    141 - 210
CISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLP    211 - 280
TGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC    281 - 350
LRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN    351 - 420
RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLE    421 - 490
ASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLE    491 - 560
TSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFSSQEEVSLSHVRPEDCEKGGLKNINLII    561 - 630
ILTFILVSAILLTTLAACCCVRRQKFNQQYKA                                          631 - 662
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Text Mined References (29)

PMID Year Title
26584734 2016 Methylation of an intragenic alternative promoter regulates transcription of GARP.
26357016 2015 The GARP complex is required for cellular sphingolipid homeostasis.
25017104 2014 Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
24098777 2013 GARP is regulated by miRNAs and controls latent TGF-?1 production by human regulatory T cells.
23886662 2013 A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
23817571 2013 Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
23817569 2013 A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
23650616 2013 miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant.
22278742 2012 GARP regulates the bioavailability and activation of TGF?.
22070912 2012 The C11orf30-LRRC32 region is associated with total serum IgE levels in asthmatic patients.
More...