Tbio GGTLC2 Glutathione hydrolase light chain 2

Protein Summary

Description

This gene encodes a protein related to enzymes that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides. Unlike similar proteins, the encoded protein contains only the light chain portion and may not have catalytic activity. Alternative splicing results in multiple transcript variants. There are several related family members and related pseudogene for this gene situated in the same region of chromosome 22. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q14390
• A1A516
• A2VCM9
• Q5NV76
• Q6ISH0

Gene Name

• GGTLC2

Ensembl ID

• ENST00000480559
• ENSP00000419751
• ENSG00000100121

Symbol

• GGTL4
• GGTL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.53
cellular component	0.52
cell type or tissue	0.51
tissue sample	0.47
disease	0.4

Protein Classes

PANTHER Classes

Protein / ... / Protease / Glutathione Hydrolase Light Chain 2

DTO Classes

Protein / Enzyme / Protease / Glutathione Hydrolase Light Chain 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0