Tclin PDE1C Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Protein Summary

Description

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q14123
• B3KPC6
• E9PE92
• Q14124
• Q8NB10
• Cam-PDE 1C

Gene Name

• PDE1C

Ensembl ID

• ENST00000321453
• ENSP00000318105
• ENSG00000154678
• ENST00000396182
• ENSP00000379485
• ENST00000396184
• ENSP00000379487
• ENST00000396191
• ENSP00000379494

Symbol

• Hcam3
• DFNA74
• hCam-3
• cam-PDE 1C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
trait	0.86
virus perturbation	0.85
gene perturbation	0.74
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.84   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1