Property Summary

NCBI Gene PubMed Count 21
Grant Count 19
R01 Count 11
Funding $1,316,226.43
PubMed Score 23.73
PubTator Score 21.39

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (21)

Disease log2 FC p
malignant mesothelioma 1.500 0.000
astrocytic glioma -2.800 0.003
ependymoma -2.600 0.010
oligodendroglioma -2.500 0.010
glioblastoma -1.900 0.004
osteosarcoma -1.867 0.023
cystic fibrosis -1.775 0.000
atypical teratoid / rhabdoid tumor -3.200 0.000
medulloblastoma, large-cell -2.700 0.000
primitive neuroectodermal tumor -2.900 0.000
interstitial cystitis 1.100 0.013
lung adenocarcinoma -1.500 0.000
pediatric high grade glioma -1.800 0.001
group 4 medulloblastoma 1.700 0.000
non-small cell lung carcinoma -1.600 0.000
breast carcinoma -1.400 0.000
Pick disease -1.300 0.032
progressive supranuclear palsy -1.400 0.007
Breast cancer -2.900 0.000
ductal carcinoma in situ -1.200 0.015
invasive ductal carcinoma -1.500 0.020

Gene RIF (8)

PMID Text
25620587 PDE1C is a proliferation-associated gene in glioblastoma multiforme cells in vitro.
25608528 PDE1C is an important regulator of SMC proliferation, migration, and neointimal hyperplasia, in part through modulating endosome/lysosome-dependent PDGFRbeta protein degradation via low-density lipoprotein receptor-related protein-1.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20110084 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19240061 Observational study of gene-disease association. (HuGE Navigator)
17726023 PDE1C1 is expressed at high levels in human cardiac myocytes with an intracellular distribution distinct from that of PDE3A
16455054 PDE1C levels decreased in all conditions that inhibited proliferation
11156964 HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases

AA Sequence

MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAAT      1 - 70
VLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFV     71 - 140
ERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALV    141 - 210
SFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH    211 - 280
IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIK    281 - 350
AMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS    351 - 420
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEG    421 - 490
SAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGA    491 - 560
SGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTD    561 - 630
GTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQ    631 - 700
NISHNWNRK                                                                 701 - 709
//

Text Mined References (22)

PMID Year Title
25620587 2016 Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro.
25608528 2015 Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.
23509613 2013 Genome-wide association study of antiphospholipid antibodies.
23472165 2013 Genome-wide association study link novel loci to endometriosis.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20110084 2010 Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
19369195 2009 Large-scale proteomics analysis of the human kinome.
19240061 2009 Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
18335582 2008 Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
17726023 2007 Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.
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