Property Summary

NCBI Gene PubMed Count 45
PubMed Score 42.67
PubTator Score 56.29

Knowledge Summary

Patent (5,823)


  Disease Sources (2)

Disease Target Count P-value
posterior fossa group B ependymoma 1530 1.48584077931614E-10
tuberculosis 1563 8.27375689256604E-9
medulloblastoma 1524 6.01153920254503E-6
atypical teratoid / rhabdoid tumor 4369 1.36855541481045E-4
medulloblastoma, large-cell 6234 2.36040775159709E-4
adult high grade glioma 2148 3.01699821361792E-4
ductal carcinoma in situ 1745 4.90996910061253E-4
adrenocortical carcinoma 1427 0.00169104638741377
invasive ductal carcinoma 2950 0.00216952756496487
astrocytic glioma 2241 0.00441413030520169
Rheumatoid Arthritis 1171 0.0276867725666979
primitive neuroectodermal tumor 3031 0.0291027051682715
Disease Target Count Z-score Confidence
Nager acrofacial dysostosis 21 3.364 1.7


  Differential Expression (12)


Accession Q14012 Q3KPF6
Symbols CAMKI



4FG7   4FG8   4FG9   4FGB  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

 GO Component (2)

MLP Assay (2)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448
652206 other 0 / 0 / 0 ML-187 activity in a kinase panel for Extended probe characterization for beta-cell apoptosis Measured in Biochemical System

Gene RIF (20)

26466644 Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha).
24841198 this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A and CaMKI and PME-1 networks may function in fine-tuning cell proliferation and stress response.
24825433 CAMK1 functional regulation subnetwork in hepatocellular carcinoma
24461366 It is one of Ca(2+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD.
23707388 Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events
23028635 structures of three CaMKIalpha truncates in apo form and in complexes with ATP
21249615 CaMKI was significantly upregulated in adrenal adenomas.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20433920 HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways

AA Sequence

CRDCCVEPGTELSPTLPHQL                                                      351 - 370

Text Mined References (54)

PMID Year Title
26466644 2015 The immunomodulatory effects of barettin and involvement of the kinases CAMK1? and RIPK2.
24841198 2014 Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
24825433 2014 CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation.
24461366 2014 Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23867755 2013 Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion.
23707388 2013 Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
23028635 2012 Crystal structures of human CaMKI? reveal insights into the regulation mechanism of CaMKI.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21301225 2011 Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II.