You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RASGRF1
Ras-specific guanine nucleotide-releasing factor 1

Protein Summary
Description
Promotes the exchange of Ras-bound GDP by GTP. The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394745
  • ENSP00000378228
  • ENSG00000058335
  • ENST00000419573
  • ENSP00000405963
  • ENST00000558480
  • ENSP00000452781

Symbol
  • CDC25
  • GNRP
  • GRF1
  • GNRP
  • GRF1
  • CDC25
  • GRF55
  • CDC25L
  • H-GRF55
  • PP13187
  • ras-GRF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.87
trait
0.86
hub protein
0.82
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.47   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.47   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0