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Tbio
RUNX2
Runt-related transcription factor 2

Protein Summary
Description
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis (PubMed:28505335, PubMed:28738062, PubMed:28703881). Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation. This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359524
  • ENSP00000352514
  • ENSG00000124813
  • ENST00000371432
  • ENSP00000360486
  • ENST00000371436
  • ENSP00000360491
  • ENST00000371438
  • ENSP00000360493
  • ENST00000465038
  • ENSP00000420707
  • ENST00000647337
  • ENSP00000495497

Symbol
  • AML3
  • CBFA1
  • OSF2
  • PEBP2A
  • CCD
  • AML3
  • CCD1
  • CLCD
  • OSF2
  • CBFA1
  • OSF-2
  • PEA2aA
  • PEBP2aA
  • CBF-alpha-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.98
co-expressed gene
0.96
biological term
0.94
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4412.42   (req: < 5)
Gene RIFs: 527   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4412.42   (req: >= 5)
Gene RIFs: 527   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0