Tclin CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C

Protein Summary

Description

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q13936
• B2RUT3
• E9PDJ0
• Q13917
• Q13918
• Q13919
• Q13920
• Q13921
• Q13922
• Q13923
• Q13924
• Q13925
• Q13926
• Q13927
• Q13928
• Q13929
• Q13930
• Q13932
• Q13933
• Q14743
• Q14744
• Q15877
• Q4VMI7
• Q4VMI8
• Q4VMI9
• Q6PKM7
• Q8N6C0
• Q99025
• Q99241
• Q99875

Gene Name

• CACNA1C

Ensembl ID

• ENST00000344100
• ENSP00000341092
• ENSG00000151067
• ENST00000347598
• ENSP00000266376
• ENST00000399591
• ENSP00000382500
• ENST00000399595
• ENSP00000382504
• ENST00000399597
• ENSP00000382506
• ENST00000399601
• ENSP00000382510
• ENST00000399603
• ENSP00000382512
• ENST00000399606
• ENSP00000382515
• ENST00000399621
• ENSP00000382530
• ENST00000399629
• ENSP00000382537
• ENST00000399637
• ENSP00000382546
• ENST00000399638
• ENSP00000382547
• ENST00000399641
• ENSP00000382549
• ENST00000399644
• ENSP00000382552
• ENST00000399649
• ENSP00000382557
• ENST00000399655
• ENSP00000382563
• ENST00000402845
• ENSP00000385724
• ENST00000642583
• ENSP00000494999
• ENSG00000285479
• ENST00000643038
• ENSP00000494095
• ENST00000643138
• ENSP00000496049
• ENST00000643701
• ENSP00000496458
• ENST00000643858
• ENSP00000495576
• ENST00000644048
• ENSP00000494782
• ENST00000644235
• ENSP00000494058
• ENST00000644369
• ENSP00000494765
• ENST00000644660
• ENSP00000496749
• ENST00000644691
• ENSP00000494420
• ENST00000644891
• ENSP00000496681
• ENST00000645584
• ENSP00000494018
• ENST00000645965
• ENSP00000493890
• ENST00000646257
• ENSP00000493573
• ENST00000647062
• ENSP00000495080
• ENST00000647327
• ENSP00000493781
• ENST00000647521
• ENSP00000495678

Symbol

• CACH2
• CACN2
• CACNL1A1
• CCHL1A1
• TS
• LQT8
• CACH2
• CACN2
• CaV1.2
• CCHL1A1
• CACNL1A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.96
biological process	0.95
biological term	0.94
kinase	0.9

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1c Subfamily / Voltage-dependent L-type Calcium Channel Subunit Alpha-1c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1222.9   (req: < 5)

Gene RIFs: 306   (req: <= 3)

Antibodies: 472   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1222.9   (req: >= 5)

Gene RIFs: 306   (req: > 3)

Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 124

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 35