Property Summary

NCBI Gene PubMed Count 17
PubMed Score 37.33
PubTator Score 11.15

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung adenocarcinoma 2714 1.03712362066117E-7
ovarian cancer 8492 1.17344012296524E-5
lung cancer 4473 5.1180632112822E-5
Pick disease 1893 9.23424379537051E-5
group 4 medulloblastoma 1875 2.91243702629988E-4
Breast cancer 3099 3.93666656020532E-4
glioblastoma 5572 6.18947592686639E-4
medulloblastoma, large-cell 6234 0.00108515486391054
active Crohn's disease 918 0.00536066506815402
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00709287368848859
astrocytoma 1493 0.00913905227405472
chronic rhinosinusitis 512 0.0104638792745031
progressive supranuclear palsy 674 0.0124123270282595
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0142749497688562
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0209847199809347
spina bifida 1064 0.035817889435841
Disease Target Count Z-score Confidence
Pyloric stenosis 9 3.13 1.6


  Differential Expression (16)


Accession Q13907 B4E155 Q32Q13 Q53GQ6 Q86U81 Q8WUX8 Q96IZ4 Q9BQ74
Symbols IPP1


PANTHER Protein Class (1)


2DHO   2I6K   2ICJ   2ICK  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
S.cerevisiae OMA EggNOG

Gene RIF (5)

25950736 The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of Lewy body formation.
20955688 Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients.
20877624 Observational study of gene-disease association. (HuGE Navigator)
18660489 Observational study of gene-disease association. (HuGE Navigator)
14629038 only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity

AA Sequence

NLNHLNQFVDHEKIYRM                                                         211 - 227

Text Mined References (22)

PMID Year Title
25950736 2015 Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
21269460 2011 Initial characterization of the human central proteome.
20955688 2010 Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
18660489 2008 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
17250851 2007 The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis.
17202134 2007 IDI2, a second isopentenyl diphosphate isomerase in mammals.