Property Summary

NCBI Gene PubMed Count 28
PubMed Score 8.71
PubTator Score 47.84

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Myopia 99
Disease Target Count P-value
psoriasis 6685 3.53473594967665E-145
non-small cell lung cancer 2798 1.38256540420326E-8
lung carcinoma 2844 1.31597301117053E-7
tuberculosis 1563 6.46029526445012E-7
osteosarcoma 7933 4.55322973526827E-6
lung cancer 4473 1.14571111394031E-5
acute quadriplegic myopathy 1157 1.64759017486035E-5
ovarian cancer 8492 9.83737100228376E-5
colon cancer 1475 5.49298537888652E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 6.1044891391284E-4
atypical teratoid / rhabdoid tumor 4369 0.00125073112929341
pediatric high grade glioma 2712 0.0033972923576686
glioblastoma 5572 0.00367183157017876
astrocytic glioma 2241 0.00472524669576721
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00972892684497316
ependymoma 2514 0.0102428587157758
aldosterone-producing adenoma 664 0.0123108751585619
adrenocortical carcinoma 1427 0.0151760684434672
oligodendroglioma 2849 0.020605286549351
Breast cancer 3099 0.0238523710285762
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0288794907773375
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0440428446615401
Disease Target Count Z-score Confidence
Duchenne muscular dystrophy 602 4.013 2.0

Expression

Synonym

Accession Q13884 A8K9E0 O14912 Q4KMG8
Symbols A1B
SNT2
BSYN2
59-DAP
DAPA1B
SNT2B1
TIP-43

Gene

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG

Gene RIF (3)

PMID Text
24975899 SNTB1 and MCPH1 are located on chromosome 8, which may be involved in neuroticism, avoidant personality and depression.
22721673 Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein syntrophin
16192269 beta1-syntrophin acts through a class-I PDZ interaction with the C terminus of ABCA1 to regulate the cellular distribution and activity of the transporter

AA Sequence

MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCR      1 - 70
GAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILIS     71 - 140
KIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEI    141 - 210
GWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRS    211 - 280
KDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTE    281 - 350
KDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD    351 - 420
LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSS    421 - 490
DDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA                          491 - 538
//

Text Mined References (37)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24975899 2014 Association of microcephalin 1, syntrophin-beta 1, and other genes with automatic thoughts in the Japanese population.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
23933737 2013 Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia.
23406873 2013 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
More...