Property Summary

NCBI Gene PubMed Count 80
PubMed Score 111.49
PubTator Score 124.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (7)

Disease Target Count P-value
lung carcinoma 2844 2.89840634907834E-19
Breast cancer 3099 5.52957930653402E-16
pancreatic cancer 2300 9.72865497276166E-10
malignant mesothelioma 3163 2.69146481848661E-9
non-small cell lung cancer 2798 8.70488256182037E-9
tuberculosis 1563 4.32013792778957E-7
intraductal papillary-mucinous adenoma (IPMA) 2956 6.42142113159189E-5
breast carcinoma 1614 7.05022569725734E-5
lung cancer 4473 8.27105479724508E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 3.77282035416626E-4
interstitial cystitis 2299 4.94670186887124E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00287595421187681
invasive ductal carcinoma 2950 0.0122628700794574
primary pancreatic ductal adenocarcinoma 1271 0.0232548816043876
esophageal adenocarcinoma 737 0.0391815851390946
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Junctional epidermolysis bullosa 9 0.0 5.0
Disease Target Count Z-score Confidence
Epidermolysis bullosa 21 7.212 3.6
Amelogenesis imperfecta 26 0.0 4.0
Disease Target Count Z-score Confidence
Dental enamel hypoplasia 12 3.829 1.9

Expression

Synonym

Accession Q13751 D3DT88 O14947 Q14733 Q9UJK4 Q9UJL1
Symbols AI1A
LAM5
LAMNB1
BM600-125KDA

Gene

  Ortholog (11)

 CSPA Cell Line (2)

Gene RIF (45)

PMID Text
25867809 An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set).
25769099 Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples.
25708563 Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations.
25032755 LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma.
24978847 Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies.
24742657 Microarray analysis indicates HIV-1 Tat-induced upregulation of laminin, beta 3 (LAMB3) in primary human brain microvascular endothelial cells
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of laminin, beta 3 (LAMB3) in primary human brain microvascular endothelial cells
24494736 Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity.
23958762 an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta
23769655 data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa
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AA Sequence

MRPFFLLCFALPGLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETYCTQYGEWQMKCCKCD      1 - 70
SRQPHNYYSHRVENVASSSGPMRWWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFG     71 - 140
KTWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQE    141 - 210
VGEITNLRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVHDVCV    211 - 280
CQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHT    281 - 350
EGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGL    351 - 420
TYANPQGCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLS    421 - 490
PQCNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLT    491 - 560
GPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSK    561 - 630
IEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPRDLESLDRSFNGLLTMYQRKR    631 - 700
EQFEKISSADPSGAFRMLSTAYEQSAQAAQQVSDSSRLLDQLRDSRREAERLVRQAGGGGGTGSPKLVAL    701 - 770
RLEMSSLPDLTPTFNKLCGNSRQMACTPISCPGELCPQDNGTACGSRCRGVLPRAGGAFLMAGQVAEQLR    771 - 840
GFNAQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPDTDAATIQ    841 - 910
EVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQAEAEEARSRAHAVEGQV    911 - 980
EDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLRPAEKLVTSMTKQLGDFWTRMEELRHQA    981 - 1050
RQQGAEAVQAQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETM   1051 - 1120
EMMDRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHINGRVLYYATCK                     1121 - 1172
//

Text Mined References (81)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
25867809 2015 High Diagnostic Accuracy Based on CLDN10, HMGA2, and LAMB3 Transcripts in Papillary Thyroid Carcinoma.
25769099 2015 Novel ENAM and LAMB3 mutations in Chinese families with hypoplastic amelogenesis imperfecta.
25708563 2015 Junctional epidermolysis bullosa with LAMB3 splice-site mutations.
25032755 2015 Overexpression of ?3 Chains of Laminin-332 is Associated With Clinicopathologic Features and Decreased Survival in Patients With Pancreatic Adenocarcinoma.
24978847 2015 A case of linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies.
24494736 2015 Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity.
23958762 2013 LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.
23769655 2013 Genetic analysis of epidermolysis bullosa: identification of mutations in LAMB3 and COL7A1 genes in three families.
23632796 2014 Whole-exome sequencing, without prior linkage, identifies a mutation in LAMB3 as a cause of dominant hypoplastic amelogenesis imperfecta.
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