Tclin ATP1A4 Sodium/potassium-transporting ATPase subunit alpha-4

Protein Summary

Description

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13733
• Q504T2
• Q7Z4I9
• Q8TBN8
• Q8WXA7
• Q8WXH7
• Q8WY13
• Na(+)/K(+) ATPase alpha-4 subunit

Gene Name

• ATP1A4

Ensembl ID

• ENST00000368081
• ENSP00000357060
• ENSG00000132681
• ENST00000470705
• ENSP00000433094

Symbol

• ATP1AL2
• ATP1A1
• ATP1AL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.99
tissue sample	0.63
gene perturbation	0.62
interacting protein	0.61

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Sodium/potassium-transporting Atpase Subunit Alpha-4

Protein / Transporter / Cation Transporter / Sodium/potassium-transporting Atpase Subunit Alpha-4

Protein / Hydrolase / Sodium/potassium-transporting Atpase Subunit Alpha-4

DTO Classes

Protein / Transporter / P-type Atpases / Na+/k+-atpases / Sodium/potassium-transporting Atpase Subunit Alpha-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.87   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 9   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.87   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3