Tclin HTR4 5-hydroxytryptamine receptor 4

Protein Summary

Description

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q13639
• C4WYH4
• Q546Q1
• Q684M0
• Q712M9
• Q96KH9
• Q96KI0
• Q9H199
• Q9NY73
• Q9UBM6
• Q9UBT4
• Q9UE22
• Q9UE23
• Q9UQR6
• 5-HT-4

Gene Name

• HTR4

Ensembl ID

• ENST00000360693
• ENSP00000353915
• ENSG00000164270
• ENST00000362016
• ENSP00000355037
• ENST00000377888
• ENSP00000367120
• ENST00000517929
• ENSP00000435904
• ENST00000520514
• ENSP00000427913
• ENST00000521530
• ENSP00000428320
• ENST00000521735
• ENSP00000430979
• ENST00000522588
• ENSP00000430874
• ENST00000631296
• ENSP00000485747

Symbol

• 5-HT4
• 5-HT4R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
ligand (chemical)	0.95
cell type or tissue	0.76
microRNA	0.7
biological term	0.65

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / 5-hydroxytryptamine Receptor 4

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / 5-hydroxytryptamine Receptor / 5-ht4 Receptor / 5-hydroxytryptamine Receptor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.79   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 391   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.79   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 441

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7