| Tbio | Interferon regulatory factor 5 |
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Colitis, Ulcerative | 59 | 0.0 | 0.0 |
| Inflammatory Bowel Disease 14 | 1 | 0.0 | 0.0 |
| Lupus Erythematosus, Systemic | 67 | 0.0 | 0.0 |
| Scleroderma, Systemic | 13 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.5e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Systemic lupus erythematosus | 194 | 5.735 | 2.9 |
| Systemic scleroderma | 60 | 3.99 | 2.0 |
| Crohn's disease | 321 | 0.0 | 3.0 |
| ulcerative colitis | 1819 | 0.0 | 3.0 |
| Disease | Target Count |
|---|---|
| Diffuse cutaneous systemic sclerosis | 17 |
| Primary biliary cirrhosis | 51 |
| limited scleroderma | 19 |
MNQSIPVAPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKE 1 - 70 TGKYTEGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPEDYSFGA 71 - 140 GEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAPDPSPLAPPPGNPAGF 141 - 210 RELLSEVLEPGPLPASLPPAGEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPHGCRLFYSQLE 211 - 280 ATQEQVELFGPISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPC 281 - 350 ASAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVP 351 - 420 VAARLLLEMFSGELSWSADSIRLQISNPDLKDRMVEQFKELHHIWQSQQRLQPVAQAPPGAGLGVGQGPW 421 - 490 PMHPAGMQ 491 - 498 //
